First Toa Payoh Primary School started in 1968 in Toa Payoh , Lorong 1. On 2 January 2002 the school merged with Braddell, San Shan and Westlake Primary School and was housed in the present premises at Toa Payoh Lorong 8.
Miss Rosalind Chia Peck Lan was appointed Principal of the school in December 2001. In December 2008, Miss Pearly Ng Por Joo was appointed as the next Principal. In December 2016, Mr Chua Choon Guan was appointed as the next Principal. In December 2023, Mrs Jennifer Choy took over and is the Principal for First Toa Payoh Primary School.